Erection Health

Popular cholesterol – busting drugs – statins – appear to lower men’s PSA values along with their cholesterol levels, according to researchers in the Duke Prostate Center and the Durham Veterans Affairs Medical Center. But whether the drugs prevent prostate cancer growth or just mask it is not known yet.

“Previous studies had shown that men taking statins were less likely to develop advanced forms of prostate cancer but no one had looked at the relationship between the drugs and prostate-specific antigen, or PSA, a biomarker that is correlated with cancer growth and is the most common prostate cancer screening tool,” said Stephen Freedland, M.D., a urologist at Duke and senior investigator on the study. “Our study represents a move to understand if and how statins influence prostate biology and whether they are really reducing cancer risk, or simply making PSA a less effective screening tool.“

The study was published in the October 28, 2008 issue Journal of the National Cancer Institute. The research was funded by the United States Department of Veterans Affairs, The United States Department of Defense and the American Urological Association Foundation’s Astellas Rising Star in Urology Award, given to Freedland.

The researchers reviewed the medical records of 1214 men who were prescribed statins between 1990 and 2006 at the Durham Veterans Affairs Medical Center. Men with prostate cancer were excluded from the study. 

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They found that PSA levels declined by an average of about four percent after starting statins, compared to no decline in the year before starting the statins, Freedland said. Bigger declines occurred in men who took higher doses of statins and who had the largest decreases in cholesterol levels. Also, the higher the PSA levels were initially, the more they were seen to decline, Freedland said.

“This is important because we had some men who started with PSA levels that looked to be headed in the direction of a recommended biopsy to look for prostate cancer, but they weren’t there quite yet,” said Robert Hamilton, M.D., a urologist at the University of Toronto, who served as this study’s lead investigator while he was a research fellow at Duke. “In a good proportion of these men, the PSA levels declined sufficiently to a point where physicians might not recommend a biopsy, so it’s really important that we understand what’s at work here, so we can be sure we’re not missing cancers because of deceptively low PSA levels.“

“Our next step will be to further investigate the interplay between statins and prostate biology to determine whether their effect on PSA corresponds to, or is independent of, cancer growth,” Freedland said. “Depending on the outcomes, this could have big public health implications, whether we need to change the way we screen men who are taking statins or we are able to harness the mechanism by which statins work to reduce risk or even treat cancer.” Kamagra pharmacy

Statins were the most commonly prescribed class of drugs in the United States in 2007 and they work by blocking the production of a critical enzyme the body needs to make cholesterol. There are several types of cholesterol found in the blood; when the level of so-called “bad” cholesterol, or low density lipoprotein (LDL) is too high and concentrations of “good” cholesterol, or high density lipoprotein (HDL) too low, it can lead to cardiovascular disease.

Other researchers involved in this study include Kenneth Goldberg of the Durham Veterans Affairs Medical Center and Duke; and Elizabeth Platz, of the Johns Hopkins Bloomberg School of Public Health.

In the last few years, the treatment options for prostate problems have expanded. The German Institute for Quality and Efficiency in Health Care (IQWiG) has assessed new treatments and warns that some new surgical techniques are being heavily promoted without first having been adequately evaluated.

Informed choices are essential

For many men, the symptoms of this condition are just annoying. But for some men, an enlarged prostate means going to the toilet so often that a good night’s sleep has become a thing of the past. Most of the time the cause is an enlarged prostate, a condition doctors call “benign prostatic hyperplasia”. One in five men in their 50s are affected – and the majority of men in their 70s will have symptoms.

The treatment choices have greatly expanded in recent years. However IQWiG’s evaluation of the research raises questions about many surgical techniques. According to the Institute’s Director, Professor Peter Sawicki, “Not everything that is new is necessarily an improvement. Better information is necessary to help men and their doctors weigh up the advantages and disadvantages of the various treatments.”

To that end, IQWiG has published easy-to-understand summaries of the research in this area on IQWiG’s website for the public, http://www.informedhealthonline.org. Included is information on managing prostate symptoms, medicines and surgical options as well as the stories of men who have used different treatments.

Most men with BPH symptoms will never need surgery

According to researchers’ best estimates, about 3 out of every 10 men in Europe will handle their prostate symptoms without medication or surgery and perhaps only 1 in 10 will have surgery. The rest will use medications, including herbal medicines, if their symptoms become too troublesome.

“In Germany and other European countries, drugs called alpha blockers have taken over as the most common treatment choice for benign prostatic hyperplasia,” said Professor Sawicki. “These drugs were originally developed to reduce high blood pressure, but prostate symptoms will also improve at least a little for 60% of the men who use them.” Buy Benicar for treating high blood pressure.

In analysing the research results for surgery, the Institute concluded that the original surgical procedures still have the best results. A few of the new surgical techniques appear to have good results – for example, possibly shortening the time needed in hospital. But more research is needed to confirm this. And most of the new techniques use equipment that has not yet been tested in enough trials.

“Prostate surgery can be very effective, but the adverse effects are a major concern for many men. Some of the newer techniques might have fewer adverse effects, but they may be so much less effective that the symptoms return, as bad as ever, within a couple of years,” Professor Sawicki said.

Two-thirds of patients stopped using Uprima, a drug commonly prescribed for erection problems, because they felt it wasn’t effective, according to a large-scale study published in the July issue of the urology journal BJU International.

And 70 per cent of family doctors who expressed an opinion using an official National Health Service (NHS) drug feedback form felt the drug wasn’t effective.
Researchers at the UK’s Drug Safety Research Unit and University of Portsmouth analysed prescribing data for 11,185 patients seen by NHS family doctors.

The data was gathered from official Green Form Questionnaires that ask doctors to record any significant events recorded in a patient’s notes after prescribing newly marketed medicines.

Key findings on erectile dysfunction drug:

• 65 per cent of doctors said their patient stopped taking Uprima because they felt it wasn’t effective and 14 per cent said the patient didn’t request a further prescription. (68 per cent of GPs responded to the question).
• Further analysis showed that 59 per cent of patients who didn’t find it effective stopped taking Uprima after a month and a further 23 had joined them by month two. (Timescale information was recorded for 79 per cent of patients who judged the drug ineffective).
• 70 per cent of doctors said they didn’t think the drug was effective and 30 per cent said it was. (65 per cent of GPs responded to the question)
• 28.5 per cent of the total patient sample had a history of diabetes, 18.8 per cent had heart disease and 37.2 per cent had tried generic viagra online. 7.5 per cent were receiving both Uprima and nitrate therapy for angina.
• The most common adverse drug reactions were headache and nausea, in line with the clinical trials and as listed in the Summary of Product Characteristics by the manufacturers.
• The average age of the subjects was 61 and all but eight were male. Three of the women were prescribed Uprima for decreased libido, pain and sexual arousal problems. Prescribing information was not provided for the other five.
• Most patients (99 per cent) received the manufacturer’s recommended dose of 2-3mg, with the remainder receiving between 4-12mg. (Starting dose information was completed on 79 per cent of forms).
• 99 deaths (just under one per cent of the total sample) were recorded on the forms. The most frequently reported cause of death was heart attack (27 patients), followed by heart disease (nine) and lung cancer (five). In 21 cases the cause of death could not be established by the researchers.

The 11,185 forms covered patients who were first prescribed Uprima between October 2001 – three months after the drug was launched in the UK – and December 2002. Just over 21,000 Questionnaires were issued and 57 per cent of GPs responded.

At least six months after the first prescription for Uprima was issued for each patient, their family doctor was sent a Green Form Questionnaire that requested details about the patient’s age and sex and their use of Uprima.

They were also asked to record any significant events that had occurred since the patient was prescribed Uprima, such as suspected drug reactions, unexpected deterioration or improvement in the patient’s condition, referral to a specialist or any clinically important changes in laboratory tests.

The form also included questions on diseases commonly associated with erectile dysfunction – such as diabetes and heart disease ” together with previous use of similar drugs and co-prescribing of medication for angina.

“Prescription-Event Monitoring provides surveillance on a national scale after new drugs are launched” explains lead researcher Professor Saad Shakir.

“Because family doctors are not approached before the decision to treat a patient has been made, they are not subject to detailed inclusion or exclusion criteria. The decision to prescribe is made purely as a result of their clinical knowledge of the patient and the drug involved.”

“The result is real world clinical data that provides information of illness and death in patients treated with newly marketed drugs ” a valuable tool in drug safety assessment.”

Weak erection connotes debility to sustain erection during sexual intercourse. It is a major problem suffered with advancement of age and is experience more commonly after the age of 40. Weak erection is a state where a male is not able to get required erection level for penetration during intercourse. Weak erection is high sex dysfunction among males and is caused due to inadequate blood supply in penis. This may happen due to multiple reasons including stress, distractions or underlying physical conditions.

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Although it can depend upon two factor. Weak erections happen in two forms- primary and secondary. Primary weak erections refers to a state where problem persists since the first time and secondary erection prevails in the situation where earlier a man used to have good erection but then he start suffering from dysfunction in erections. Primary erectile dysfunction can sometime happen due to innate physical conditions and may be non-curable.

Causes of weak erections

The particular reasons for the problem of weak erections are still enigma among scientist but the problem is considered more as a synonym with age factor. Once a man age advances, he start loosing the strength, certain physical changes due to ageing and other factors leads to weak erection. Though rarely the problem occurs due to underlying physical conditions but it is more to do with psychological factors. Chronic Stress and tensed mind, differences in couples, distracted mind are major triggers for weak erection. By the way, if the erections get weak occasionally than it’s not the area of concern but if problem persist for more than 50% times than probably a man is suffering from Weak erection. Men with Diabetes Mellitus are at higher risk to experience the erection dysfunction.

Kamagra Tablets and Jellies are a cheap, effective treatment for Male Erectile Dysfunction (E.D). Kamagra is generic Sildenafil Citrate and is produced by company Ajanta Pharma. Kamagra tablets and jelly contain the same ingredients and perform in a similar way to its more expensive counterpart Viagra produced by Kamagra pharmacy. It takes approximately 45 minutes for Kamagra tablets and jellies to start working and is effective for 4-6 hours.

INFORMATION ABOUT KAMAGRA:

Two chemicals are produced by the male body whilst sexually aroused, Cyclic GMP which causes the muscles in the arterial wall of the penis to relax allowing blood to flow in and phosphodiesterase type 5 (PDE-5) which decreases erections. Kamagra contains an ingredient called Sildenafil. Sildenafil is a PDE-5 inhibitor. Whilst active Kamagra causes a vigorous build up of Cyclic GMP causing the penis to stay erect. It must be noted that sexual simulation is required in order for Kamagra to become effective. It is recommended that no more than one 100mg tablet is taken in any 24 hr period.

POSSIBLE SIDE EFFECTS OF KAMAGRA:

Under normal circumstances, side effects are mild and can include upset stomach, headache and facial flushing. Other possible, less common side effects are sensitivity to light and a bluish / blurred vision. If experiencing chest pains, nausea or dizziness during sex, seek immediate medical advice.

PRECAUTIONS BEFORE TAKING KAMAGRA:

Kamagra must be used under a doctors supervision. It is strongly recommended that you seek medical advice (all instances) to establish if your heart is healthy enough for sexual activity. Most importantly Kamagra should never be taken if you take any medicines that contain nitrates. Nitrates are commonly contained in drugs for the treatment of Angina. Examples of these are Nitroglycerin, Isosorbide Mononitrate and Isosorbide Dinitrate. Nitrates can also be found in recreational drugs such as Amyl Nitrate (known as Poppers). If you are unsure what nitrates are or need to establish if any medicines you are taking contain nitrates consult your doctor. Taking Kamagra with any medication containing nitrates can cause blood pressure to drop to an unsafe level. Possible effects can be dizziness, heart attack or stroke.

If you have ever suffered from any of the following conditions inform your doctor before taking Kamagra:

• Kidney / Liver Problems
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• High / Low Blood Pressure
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• Penis deformity such as Peyronies Disease
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• Allergy to Sildenafil

Your doctor can then inform you if it is safe to take Kamagra tablets, and if so, the appropriate dose. All Kamagra tablets sold on this site are 100mg. Smaller doses can be achieved by splitting the pills. For example, if you are over the age of 65 or have had liver /kidney problems, the appropriate dose may be 25mg. Also if you are taking alpha blockers no more than 25 mg of Kamagra should be taken within 4 hours of your alpha blocker dose. Under no circumstances should Kamagra be taken more than once a day. Kamagra should not be taken by women or by children under the age of 18.

Kamagra is administered in three strengths:

• Kamagra 25 mg
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Though 50mg is the recommended dose which is usually taken by cutting a 100mg tab in half and swallowing with water. It is important to remember that only one dose should be taken per day.

Why Kamagra?

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Viagra vs Kamagra

Viagra is the brand name which is the authorized version of the medicine. When a generic version is issued for the drug the manufacturer brings out the patent for the drug. Until the patent expires no other company is given permission to manufacture the drug.

Benefits of using Kamagra:

• Generic Kamagra helps in treating erectile dysfunction
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Facts about Kamagra:

• Generic Kamagra selling prices are reasonable, as manufacturers do not have to do much investment in regard to its promotion, marketing and development.
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Precautions regarding Kamagra:

• Inform your health care professional about your complete medical history mainly regarding high or low blood pressure, blood system cancers, eye problems, anemia, erectile organ conditions and allergies.
• This drug may cause dizziness, raise slowly from the bed.
• Elderly people may be more sensitive to the effects of the drug
• Avoid the consumption of alcohol, as it can increase the side effects of the drug.